Charakterisierung der zellulären Immunantwort auf SARS-CoV-2-Infektionen

Innate and adaptive immune responses during incubation and non-severe phases of SARS-CoV-2 infections are potentially decisive for disease progression and severity. Detailed immunophenotying  studies of unfolding SARS­ CoV-2 infections are still missing. The strong focus of our laboratory on immune reconstitution,  detection of virus­ specific T-cells and immunotherapies  enables us to start immediately  with i) deep phenotyping of several T- and B-cells subtypes by high-dimensional flow cytometry and single cell transcriptomics ii) detection of CoV-2-specific T-cells (via soon available peptide pools) and iii) identification  of immunodominant  viral epitopes and SARS-CoV-2-specific T-cell receptor clonotypes. These immune parameters are vital to predict disease outcome and pave the way for  new therapeutic  interventions.